New study indicates ability of oral sulforaphane to boost antioxidant response in the human brain

Our Center participated in a study with results ​just​ published ​i​n Molecular Neuropsychiatry.  This small pilot study was led by colleagues in ​The Schizophrenia Center​, along with the Departments of Psychiatry and Radiology at the Johns Hopkins School of Medicine.  Nine healthy volunteers ingested sulforaphane from broccoli​, daily for seven days.  There were increases ​in​ glutathione​ (the body’s most abundant antioxidant)​ in the blood, and in the brain at specific sites where one would hope to be able to ​reduce​ oxidative stress.  This is exciting because for the first time, a systemic, easily accessible indicator (from​ blood samples) and the same molecule measured at the site of action ​using sophisticated non-invasive imaging of specific regions of ​the brain, correlated with each other and changed following administration of sulforaphane.  This should​ aid our understanding of ​​sulforaphane’s indirect antioxidant effects ​that may help with neurological conditions like schizophrenia and autism.

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Cullman Chemoprotection Center

Cullman Chemoprotection Center

Diet-Based Prevention of Chronic Disease: Green Chemoprotection
Cullman Chemoprotection Center