Posts Categorized: Nutrition

Exciting Recent Paper on Inflammation and Nrf2

Long time Center member Dr. Dinkova-Kostova participated in research described in a very exciting paper in Nature that she co-authored along with a large team of colleagues from Harvard (US), Trinity College (Ireland), the Universities of Dundee, Cambridge, and Glascow (all UK), and elsewhere. Their study describes discovery of a Krebs cycle derivative that is a crucial anti-inflammatory metabolite which also regulates type… Read more »

New study indicates ability of oral sulforaphane to boost antioxidant response in the human brain

Our Center participated in a study with results ​just​ published ​i​n Molecular Neuropsychiatry.  This small pilot study was led by colleagues in ​The Schizophrenia Center​, along with the Departments of Psychiatry and Radiology at the Johns Hopkins School of Medicine.  Nine healthy volunteers ingested sulforaphane from broccoli​, daily for seven days.  There were increases ​in​ glutathione​ (the body’s most abundant antioxidant)​ in the blood, and in the… Read more »

Autism, Broccoli, & Urine!

Urinary Metabolites Correlate with Autism Symptom Improvements after Treatment with Sulforaphane from Broccoli We partnered with psychiatry and autism experts at the University of California, San Francisco, and industry experts, to treat children with autism spectrum disorder (ASD).  They were given a supplement that produces sulforaphane from the glucoraphanin in broccoli, daily for 12 weeks. … Read more »

Exciting updates on Moringa (the Drumstick Tree)

The Cullman Chemoprotection Center at Johns Hopkins University, in a long-term partnership with an international team led from Mexico (Universidad Nacional Autonoma de Mexico and the International Moringa Germplasm Collection), has collaborated to publish a pair of studies in the Nature journal Scientific Reports.  Neither study received funding from the NIH or other traditional sources… Read more »

Exciting News for the Spring

Much has happened since we last posted an update: At least 4 new papers were published by members of the CCC: Dr. Dinkova-Kostova was a co-author of a very exciting paper in Nature that describes a Krebs cycle derivative that is a crucial anti-inflammatory metabolite which also regulates type I interferons. This discovery may yield… Read more »

Dr. Fahey talks about Moringa oleifera in a new podcast

Dr. Fahey recently talked about the edible tropical tree Moringa on SmartDrugSmarts, with host Jesse Lawler and Lisa Curtis.  In this 38 minute podcast  Fahey discussed research on Moringa at the Chemoprotection Center, including their plans to evaluate it in the clinic.  

More Public Interest in Sulforaphane

We have been pleasantly surprised to see a series of very understandable, and well documented videos appear recently.  They are unsolicited, and we have no connection to the narrator or his organization, nor were we interviewed for them.  They do a good job of presenting some concepts (and in a couple of them they very… Read more »

“Indirect Antioxidant” Defined

Over the years many people have asked what we mean when we call sulforaphane an “indirect antioxidant”.  We have just posted a FAQ entry that we hope helps to answer that question.  Here is our answer: Q:  You and others frequently call sulforaphane an indirect antioxidant.  What does that mean? A:  Oxidative stress is thought to be… Read more »

The Bioavailability of Nutritional Supplements Rich in Sulforaphane

We have a new paper that was just published in the journal Molecular Nutrition and Food Research.  In it we discuss the fact that sulforaphane (SF) from broccoli sprouts must be stabilized for use in nutritional supplements.   We present data on person-to-person variation in bioavailability, and we give examples of good availability of a… Read more »