Long time Center member Dr. Dinkova-Kostova participated in research described in a very exciting paper in Nature that she co-authored along with a large team of colleagues from Harvard (US), Trinity College (Ireland), the Universities of Dundee, Cambridge, and Glascow (all UK), and elsewhere. Their study describes discovery of a Krebs cycle derivative that is a crucial anti-inflammatory metabolite which also regulates type… Read more »
Posts Categorized: Chronic Disease
Cullman Chemoprotection Center members Drs. Dinkova-Kostova and Dayalan Naidu participated in a fascinating study recently published in the journal Brain, showing that increasing the body’s antioxidant defenses was protective against epilepsy in an animal model. They tested this novel strategy to increase endogenous antioxidant defenses using RTA 408, a drug synthesized by Reata Pharmaceuticals that… Read more »
Sulforaphane, was isolated by us from broccoli and broccoli sprouts many years ago. It was developed by us and many others around the world as a chemoprotective phytochemical — a compound from plants that is not required for life (like proteins, carbohydrates, fats, vitamins and minerals), but which enhances health. Many laboratory and animal studies… Read more »
Our Center participated in a study with results just published in Molecular Neuropsychiatry. This small pilot study was led by colleagues in The Schizophrenia Center, along with the Departments of Psychiatry and Radiology at the Johns Hopkins School of Medicine. Nine healthy volunteers ingested sulforaphane from broccoli, daily for seven days. There were increases in glutathione (the body’s most abundant antioxidant) in the blood, and in the… Read more »
The Cullman Chemoprotection Center at Johns Hopkins University, in a long-term partnership with an international team led from Mexico (Universidad Nacional Autonoma de Mexico and the International Moringa Germplasm Collection), has collaborated to publish a pair of studies in the Nature journal Scientific Reports. Neither study received funding from the NIH or other traditional sources… Read more »
Much has happened since we last posted an update: At least 4 new papers were published by members of the CCC: Dr. Dinkova-Kostova was a co-author of a very exciting paper in Nature that describes a Krebs cycle derivative that is a crucial anti-inflammatory metabolite which also regulates type I interferons. This discovery may yield… Read more »
Dr. Fahey recently talked about the edible tropical tree Moringa on SmartDrugSmarts, with host Jesse Lawler and Lisa Curtis. In this 38 minute podcast Fahey discussed research on Moringa at the Chemoprotection Center, including their plans to evaluate it in the clinic.
We have been pleasantly surprised to see a series of very understandable, and well documented videos appear recently. They are unsolicited, and we have no connection to the narrator or his organization, nor were we interviewed for them. They do a good job of presenting some concepts (and in a couple of them they very… Read more »
Over the years many people have asked what we mean when we call sulforaphane an “indirect antioxidant”. We have just posted a FAQ entry that we hope helps to answer that question. Here is our answer: Q: You and others frequently call sulforaphane an indirect antioxidant. What does that mean? A: Oxidative stress is thought to be… Read more »
Last week, Dr. Fahey talked about sulforaphane on SmartDrugSmarts, in the central half hour of this 44 minute podcast.