2017

 

Aoki Y, Wehage SL, Talalay P. (2017) Quantification of skin erythema response to topical alcohol in alcohol-intolerant East Asians. Skin Res Technol.  doi: 10.1111/srt.12376. PMID:28513003

Axelsson AX, E Tubbs, B Mecham, S Chacko, HA Nenonen, Y Tang, JW Fahey, JMJ Derry, CB Wollheim, N Wierup, MW Haymond, SH Friend, H Mulder, AH Rosengren.  (2017) Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes. Science Translational Medicine 9(394): eaah4477.  14 June 2017. with supplementary content.

Dayalan Naidu, S., Dikovskaya, D., Gaurilcikaite, E., Knatko, E. V., Healy, Z. R., Mohan, H., … Dinkova-Kostova, A. T. (2017). Transcription factors NRF2 and HSF1 have opposing functions in autophagy. Scientific Reports7, 11023. http://doi.org/10.1038/s41598-017-11262-5

Dayalan Naidu S, Dinkova-Kostova AT. (2017) Regulation of the mammalian heat shock factor 1.  FEBS J. 284(11):1606-1627. doi: 10.1111/febs.13999. PMID: 28052564

Dinkova-Kostova AT, JW Fahey, RV Kostov, TW Kensler.  (2017)  KEAP1 and done? Targeting the NRF2 pathway with sulforaphane.  Trends in Food Science and Technology 1-13. http://dx.doi.org/10.1016/j.tifs.2017.02.002.

Fahey JW. (2017) Moringa oleifera medicinal potential and benefits.  Invited Chapter in The Complete Moringa: From Seedling to Fruit to Global Market.  MC Palada and AW Ebert.  AVRDC –The World Vegetable Center, Taiwan. (in press).

Fahey JW.  (2017) Moringa oleifera: a review of the medical potential.  Acta Horticulturae ISHS 1158: 209-224. DOI: 10.17660/ActaHortic.2017.1158.25 https://doi.org/10.17660/ActaHortic.2017.1158.25.

Leone A, G Diorio, W Sexton, M Schell, M Alexandrow, JW Fahey, N Kumar. (2017)  Sulforaphane for the chemoprevention of bladder cancer: Molecular mechanism targeted approach.  Oncotarget doi: 10.18632/oncotarget. 16015.

Lynch R, EL Diggins, SL Connors, AW Zimmerman, K Singh, H Liu, P Talalay, JW Fahey. (2017)  Sulforaphane from broccoli reduces symptoms of autism: A follow-up case series from a randomized double-blind study. Global Advances in Health and Medicine 6:1-7. https://doi.org/10.1177/2164957X17735826.

Quinti L, Dayalan Naidu S, Träger U, Chen X, Kegel-Gleason K, Llères D, Connolly C, Chopra V, Low C, Moniot S, Sapp E, Tousley AR, Vodicka P, Van Kanegan MJ, Kaltenbach LS, Crawford LA, Fuszard M, Higgins M, Miller JRC, Farmer RE, Potluri V, Samajdar S, Meisel L, Zhang N, Snyder A, Stein R, Hersch SM, Ellerby LM, Weerapana E, Schwarzschild MA, Steegborn C, Leavitt BR, Degterev A, Tabrizi SJ, Lo DC, DiFiglia M, Thompson LM, Dinkova-Kostova AT, Kazantsev AG. (2017)  KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington’s disease patients. Proc Natl Acad Sci U S A. 114(23):E4676-E4685. doi: 10.1073/pnas.1614943114. PMID: 28533375

2016

An SS, W Mitzner, W-Y Tang, K Ahn, A-R Yoon, J Huang, O Kilic, HM Yong, JW Fahey, S Kumar, S Biswal, ST Holgate, RA Panettieri Jr., J Solway, SB Liggett. An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma. Journal of Allergy and Clinical Immunology. DOI: http://dx.doi.org/10.1016/j.jaci.2015.12.1315.

Benedict AL, EV Knatko, RV Kostov, Y Zhang, M Higgins, S Kalra, JW Fahey, SH Ibbotson, CM Proby, P Talalay and AT Dinkova-Kostova (2016)  The Multifaceted Role of Sulforaphane in Protection against UV Radiation-Mediated Skin Damage.  Chapter 10 in Broccoli: Cultivation, Nutritional Properties and Effects on Health [Ed.] BHJ Juurlink, Nova Science Publishers, Happauge, NY.  

Bauman JE, Y Zang, M Sen, C Li, L Wang, PA Egner, JW Fahey, DP Normolle, JR Grandis, TW Kensler, DE Johnson.  (2016) Prevention of carcinogen-induced oral cancer by sulforaphane.  Cancer Prevention Research DOI: 10.1158/1940-6207.CAPR-15-0290.

Dayalan Naidu, S., Sutherland, C., Zhang, Y., Risco, A., de la Vega, L., Caunt, C. J., … Dinkova-Kostova, A. T. (2016). Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases. Molecular and Cellular Biology36(18), 2403–2417. http://doi.org/10.1128/MCB.00292-16

Fahey JW, KL Wade, SL Wehage, WD Holtzclaw, H Liu, P Talalay, E Fuchs, KK Stephenson. (2016) Stabilized sulforaphane for clinical use: Phytochemical delivery efficiency.  Molecular Nutrition and Food Research doi: 10.1002/mnfr.201600766.

Fahey JW. (2016)  Brassica: Characteristics and Properties. In Caballero B, Finglas P, and Toldrá F (eds) The Encyclopedia of Food and Health 1, pp. 469-477. Oxford: Academic Press.

Johnson TL, AT Dinkova-Kostova, and JW Fahey. (2016)  Glucosinolates from the Brassica Vegetables and their Health Effects. In Caballero B, Finglas P, and Toldrá F (eds) The Encyclopedia of Food and Health 3, pp. 248-255. Oxford: Academic Press.

Kerns ML, L Guss, JW Fahey, B Cohen, JMC Hakim, S Sung, RG Lu, and PA Coulombe. (2016) Randomized, split-body, single-blinded clinical trial of topical broccoli sprout extract assessing the feasibility of its use in keratin-based disorders. Journal of the American Academy of Dermatology doi: 10.1016/j.jaad.2016.10.009. 

Kirkwood JM, SV Singh, Y Lin, E-R Hahm, J Beumer, U Rao, C Sander, AA Tarhini, H Tawbi, L Ferris, MD Wilson, M Petrany, A Rose, JW Fahey, SA Leachman, P Cassidy, LH Butterfield and HM Zarour. (2016) Dose-response evaluation of biomarkers of broccoli sprout extract sulforaphane (BSE-SFN) in melanoma patients (Pts) with multiple atypical/dysplastic nevi (A/DN). J Clin Oncol 34: suppl; abstr e21022.

Knatko EV, M Higgins, JW Fahey, AT Dinkova-Kostova.  Loss of Nrf2 abrogates the protective effect of Keap1 downregulation in preclinical models of cutaneous squamous cell carcinoma.  Scientific Reports (Nature) 6: 25804. doi:10.1038/srep25804.

Liu H, P Talalay, JW Fahey. (2016) Biomarker-guided strategy for treatment of autism spectrum disorder (ASD). CNS & Neurological Disorders – Drug Targets. 15: 602-613 .

Olson ME, RP Sankaran, JW Fahey, MA Grusak, D Odee, W Nouman.  (2016)  Leaf protein and mineral concentrations across the “miracle tree” genus Moringa. PLOS One. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0159782#sec018.

Wise RA, Crinert G, Sethi S, Rayapudi S, Sudini KR, Sugar EA, Burke A, Thimmulappa R, Singh A, Talalay P, Fahey JW, Berenson CS, Jacobs MR, Biswal S.  Lack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: a Randomized, Double-blind, Placebo Controlled Trial. PLOS One 11(11): e0163716. doi:10.1371/journal.pone.0163716.

 

2015

Alsaid MS, Ghorab MM, Higgins M, Dinkova-Kostova AT, Shahat AA (2015) NAD(P)H: Quinone oxidoreductase 1 inducer activity of some enaminone derivatives. Biomedical Research (India) 26 (1): 7-12.

Bertrand HC, Schaap M, Baird L, Georgakopoulos ND, Fowkes A, Thiollier C, Kachi H, Dinkova-Kostova AT, Wells G. (2015) Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction Journal of Medicinal Chemistry 58(18): 7186-7194.

Bierwirth JE, KN Oftedal, GV Civille and JW Fahey. (2015) Flavor misattribution: A novel approach to improving compliance and blinding in food-based clinical interventions. NFS Journal. 1(1): 24-30.

Brown RH, C Reynolds, A Brooker, P Talalay, JW Fahey. (2015) Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways. Respiratory Research 16: DOI 10.1186/s12931-015-0253-z.

Dayalan Naidu S, Kostov RV, Dinkova-Kostova AT. (2015) Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection. Trends in Pharmacological Sciences 36 (1): 6-14.

Dinkova-Kostova AT, Abramov AY. (2015) The emerging role of Nrf2 in mitochondrial function. Free Radical Biology and Medicine 88(B): 179-188.

Dinkova-Kostova AT, Baird L, Holmström KM, Meyer CJ, Abramov AY. (2015) The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics. Biochemical Society Transactions 43: 602-610.

Fahey JW, WD Holtzclaw, SL Wehage, KL Wade, KK Stephenson, P Talalay. (2015)  Sulforaphane bioavailability from glucoraphanin-rich broccoli: Control by active endogenous myrosinase. PLOS ONE  doi 10.1371/journal.pone.0140963.

Fahey JW, KK Stephenson, and AJ Wallace. (2015) Dietary amelioration of Helicobacter infection. Nutrition Research DOI:http:/dx.doi.org/10.1016/j.nutres.2015.03.001.

Johnson TL, AT Dinkova-Kostova, and JW Fahey. (2015)  Glucosinolates from the Brassica Vegetables and their Health Effects. In Caballero B, Finglas P, and Toldrá F (eds) The Encyclopedia of Food and Health x, pp. xx. Oxford: Academic Press.

Hayes JD, Chowdhry S, Dinkova-Kostova AT, Sutherland C. (2015) Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3. Biochemical Society Transactions 43(4): 611-620.

Knatko EV, SH Ibbotson, Y Zhang, M Higgins, JW Fahey, P Talalay, RS Dawe, J Ferguson, JT-J Huang, S Zheng, A Saito, S Kalra, AL Benedict, T Honda, CM Proby, and AT Dinkova-Kostova. (2015) Nrf2 activation protects against solar-simulated ul-traviolet radiation in mice and humans. Cancer Prev Res. Published OnlineFirst March 24, 2015; doi:10.1158/1940-6207. CAPR-14-0362.

Kostov RV, Knatko EV, McLaughlin LA, Henderson CJ, Zheng S, Huang JT-J, Honda T, Dinkova-Kostova AT. (2015) Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action. Biochemical and Biophysical Research Communications 465 (3): 402-407.

Kovac S, Angelova PR, Holmström KM, Zhang Y, Dinkova-Kostova AT, Abramov AY. (2015) Nrf2 regulates ROS production by mitochondria and NADPH oxidase. Biochimica et Biophysica Acta – General Subjects 1850(4): 794-801.

Li W, Zheng S, Higgins M, Morra RP, Mendis AT, Chien C-W, Ojima I, Mierke DF, Dinkova-Kostova AT, Honda T. (2015) New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase. Journal of Medicinal Chemistry 58(11): 4738-4748.

Talalay P, and AW Zimmerman. (2015) Reply to Scahill: Behavioral outcome measures in autism. Proc Natl Acad Sci USA 112, E350.

Tebay LE, Robertson H, Durant ST, Vitale SR, Penning TM, Dinkova-Kostova AT, Hayes JD. (2015)  Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease. Free Radical Biology and Medicine  88(B): 108-146.

Wade KL, Y Ito, A Ramarathnam, WD Holtzclaw, and J W Fahey. (2015) Novel purification of active myrosinase from plants by aqueous two-phase counter-current chromatography. Phytochemical Analysis 26(1):47-53

 

2014

Baird L, Swift S, Llères D, Dinkova-Kostova AT (2014) Monitoring Keap1-Nrf2 interactions in single live cells. Biotechnology Advances 32(6): 1133-1144.

Egner PA, J-G Chen, AT Zarth, DK Ng, J-B Wang, KH Kensler, LP Jacobson, A Muñoz, JL Johnson, JD Groopman, JW Fahey, P Talalay, J Zhu, T-Y Chen, G-S Qian, SG Carmella, SS Hecht, TW Kensler. (2014) Rapid and sustainable detoxication of air-borne pollutants by broccoli sprout beverage: Results of a randomized clinical trial in China. Cancer Prevention Research 7: 813-823.

Ghorab MM, Higgins M, Alsaid MS, Arafa RK, Shahat AA, Dinkova-Kostova AT. (2014) Synthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel cyanoenone and enone benzenesulfonamides. Journal of Enzyme Inhibition and Medicinal Chemistry 29(6): 840-845.

Hayes JD, Dinkova-Kostova AT. (2014) The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Trends in Biochemical Sciences39(4): 199-218.

Ludtmann MHR, Angelova PR, Zhang Y, Abramov AY, Dinkova-Kostova AT. (2014) Nrf2 affects the efficiency of mitochondrial fatty acid oxidation.  Biochemical Journal 457(3): 415-424.

Meakin PJ, Chowdhry S, Sharma RS, Ashford FB, Walsh SV, McCrimmon RJ, Dinkova-Kostova AT, Dillon, JF, Hayes JD, Ashford ML (2014) Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not with insulin resistance. Molecular and Cellular Biology 34 (17): 3305-3320.

Singh K, SL Connors, EA Macklin, KD Smith, JW Fahey, P Talalay, and AW Zimmerman. (2014) Sulforaphane treatment of autism spectrum disorder (ASD). Proc Natl Acad Sci USA. 111(43): 15550-15555.

Zhang Y, Dayalan Naidu S, Samarasinghe K, Van Hecke GC, Pheely A, Boronina TN, Cole RN, Benjamin IJ, Cole PA, Ahn Y-H, Dinkova-Kostova AT. (2014) Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation. British Journal of Cancer 110(1): 71-82.

Zheng S, Huang JT-J, Knatko EV, Sharp S, Higgins M, Ojima I, Dinkova-Kostova AT, Honda T. (2014) Synthesis of 13C2 15N2-labeled anti-inflammatory and cytoprotective tricyclic bis(cyanoenone) ([13C2 15N2]-TBE-31) as an internal standard for quantification by stable isotope dilution LC-MS method. Journal of Labelled Compounds and Radiopharmaceuticals 57(10): 606-610.

 

2013

Baird L, Dinkova-Kostova AT (2013) Diffusion Dynamics of the Keap1-Cullin3 Interaction in Single Live Cells. Biochem Biophys Res Commun 433: 58-65.

Baird L, Llères D, Swift S, Dinkova-Kostova AT (2013) Regulatory Flexibitly in the Nrf2-mediated Stress Response is Conferred by Conformational Cycling of the Keap1-Nrf2 Protein Complex. Proc Natl Acad Sci USA (in press).

Dinkova-Kostova AT (2013) Chemoprotection Against Cancer by Isothiocyanates: A Focus on the Animal Models and the Protective Mechanisms. Top Curr Chem 329: 179-201.

Egner PA, J-B Wang, Y-R Zhu, LP Jacobson, D Ng, A Munoz, JW Fahey, J-G Chen, T-Y Chen, G-S Qian, JD Groopman, TW Kensler. (2013) Prevention of Liver Cancer in Qidong, China: Lessons from Aflatoxin Biomarker Studies. Progress Chem 25(9): 1454-1461.

Fahey JW, Kensler TW (2013) Frugal Medicine: Health-span Extension Through Green Chemoprevention. American Medical Association Virtual Mentor 15: 311-318.

Fahey JW, Stephenson KK, Wade KL, Talalay P (2013) Urease from Heliobacter pylori is Inactivated by Sulforaphane and other Isothiocyanates. Biochem Biophys Res Comm 435: 1-7.

Holmström KM, Baird L, Zhang Y, Hargreaves I, Chalasani A, Land JM, Stanyer L, Yamamoto M, Dinkova-Kostova AT, Abramov AY (2013) Nrf2 Impacts Cellular Bioenegetics by Controlling Substrate Availability for Mitochondrial Respiration. Biology Open doi:10.1242/bio20134853.

Kensler TW, Egner PA, Agyeman AS, Visvanathan K, Groopman JD, Chen J-G, Chen T-Y, Fahey JW, Talalay P (2013) Keap1-Nrf2 Signaling: A Target for Cancer Prevention by Sulforaphane. Top Current Chem 329: 163-177.

Liu H and P Talalay. (2013) Relevance of anti-inflammatory and antioxidant activities of Exemestane and synergism with sulforaphane for disease prevention. Proc Natl Acad Sci USA 110, 19065-19070.

Saito A, Higgins M, Zheng S, Li W, Ojima I, Dinkova-Kostova AT, Honda T (2013) Synthesis and Biological Evaluation of Biotin Conjugates of (a)-(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydrophenanthrene-2,6-dicarbonitrile, an Activator of the Keap1/Nrf2/ARE Pathway, for the Isolation of its Protein Targets. Bioorg Med Chem Lett 23(20):5540-5543.

Shahat AA, Alsaid MS, Alyahya MA, Higgins M, Dinkova-Kostova AT (2013) NAD(P)H:quinone Oxidoreductase 1 (NQO1) In-ducer Activity of some Saudi Arabian Medicinal Plants. Planta Medica 79: 459-464.

Tsuji PA, Stephenson KK, Wade KL, Liu H, Fahey JW (2013) Structure-activity Analysis of Flavonoids: Direct and Indirect Anti-oxidant, and Anti-inflammatory Potencies and Toxicities. Nutrition Cancer 65(7): 1014-1025. 

Yusuke U, Talalay P (2013) Sulforaphane Accelerates Acetaldehyde Metabolism by Inducing Aldehyde Dehydrogenases: Relevance to Ethanol Intolerance. Alcohol Alcoholism 48(5): 526-534. 

 

2012

Benedict AL, Knatko EV, Dinkova-Kostova AT (2012) The Indirect Antioxidant Sulforaphane Protects Against Thiopurine-mediated Photooxidative Stress. Carcinogenesis 33: 2457-2466. 

Benedict A, Mountney A, Hurtado A, Bryan KE, Schnaar RL, Dinkova-Kostova AT, Talalay P (2012) Neuroprotective Effects of Sulforaphane after Contusive Spinal Cord Injury. J Neurotrauma 29: 2576-2586.

Calabrese V, Cornelius C, Dinkova-Kostova AT, Lavicoli I, DiPaola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ (2012) Cellular Stress Responses, Hormetic Phytochemicals and Vitagenes in Aging and Longevity. Biochim Biophys Acta 1822: 754-783.

Dinkova-Kostova, AT (2012) The Role of Sulfhydryl Reactivity of Small Molecules for the Activation of the KEAP1/NRF2 Path-way and the Heat Shock Response. Scientifica Article ID 606104

Dinkova-Kostova AT, Kostov RV (2012) Glucosinolates and Isothiocyanates in Health and Disease. Trends Mol Med 18: 337-347.

Fahey JW, Wehage SL, Holtzclaw WD, Kensler TW, Egner PA, Shapiro TA, Talalay P (2012) Protection of Humans by Plant Glucosinolates: Efficiency of Conversion of Glucosinolates to Isothiocyanates by the Gastrointestinal Microflora. Cancer Prev Res 5: 603-611.

Fahey JW, Talalay P, Kensler TW (2012) Notes from the Field: “Green” Chemoprevention as Frugal Medicine. Cancer Prev Res 5: 179-188.

Johnson TL, JW Fahey (2012) Black Cohosh: Coming Full Circle? J Ethnopharmacology 141: 775-779.

Kalra S, Knatko EV, Zhang Y, Honda T, Yamamoto M, Dinkova-Kostova AT (2012) Highly Potent Activation of Nrf2 by Topical Tricyclic bis(Cyano Enone): Implications for Protection Against UV Radiation During Thiopurine Therapy. Cancer Prev Res 5: 973-981.

Kensler TW, Ng D, Cannella SG, Chen M, Jacobson LP, Munoz A, Egner PA, Chen JG, Qian GS, Chen TY, Fahey JW, Talalay P, Groopman PD, Yuan J-M, Hecht SS (2012) Modulation of Metabolism of Airborne Pollutants by Glucoraphanin-rich and Sulforaphane-rich Broccoli Sprout Beverages in Qidong, China. Carcinogenesis 33: 101-107.

Zheng S, Santosh Laxmi YR, David E, Dinkova-Kostova AT, Shiavoni KH, Ren Y, Zheng Y, Trevino I, Bumeister R, Ojima I, Wigley WC, Bliska JB, Mierke DF, Honda T (2012) Synthesis, Chemical Reactivity as Michael Acceptors, and Biological Potency of Monocyclic Cyanoenones, Novel and Highly Potent Anti-inflammatory and Cytoprotective Agents. J Med Chem 55: 4837-4846.

 

2011

Baird L, Dinkova-Kostova AT (2011) The Cytoprotective Role of the Keap1-Nrf2 Pathway. Arch Toxicol 85: 241-272.

Dinkova-Kostova AT, Wang XJ (2011) Induction of the Keap1/Nrf2/ARE Pathway by Oxidizable Diphenols. Chem Biol Interact 192: 101-106.

Egner PA, Chen JG, Wang JB, Wu Y, Sun Y, Lu JH, Zhu J, Zhang YH, Chen YS, Friesen ML, Jacobson LP, Munoz A, Ng D, Qian GS, Zhu YR, Chen TY, Botting NP, Zhang Q, Fahey JW, Talalay P, Groopman, JD, Kensler TW (2011) Bioavailability of Sulforaphane from Two Broccoli Sprout Beverages: Results of a Short-term, Cross-over Clinical Trial in Qidong, China. Cancer Prev Res 4: 384-395.

Healy ZR, Liu H, Holtzclaw D, Talalay P (2011) Inactivation of Tautomerase Activity of Macrophage Migration Inhibitory Factor by Sulforaphane: a Potential Biomarker for Anti-inflammatory Intervention. Cancer Epidemiol Biomarkers Prev 20: 1516-23.

Honda T, Dinkova-Kostova AT, David E, Padegimas EM, Sundararajan C, Visnick M, Bumeister R, Christian Wigley W (2011) Synthesis and Biological Evaluation of 1-[2-Cyano-3,12-dioxooleana-1,9(11)-dien]-28-olyl-4-ethynylimidazole. A Novel and Highly Potent Anti-inflammatory and Cytoprotective Agent. Bioorg Med Chem Lett 21: 2188-2191.

Kalra S, Zhang Y, Knatko EV, Finlayson S, Yamamoto M, Dinkova-Kostova AT(2011) Oral Azathioprine Leads to Higher Incor-poration of 6-Thioguanine in DNA of Skin than Liver: The Protective Role of the Keap1/Nrf2/ARE Pathway. Cancer Prev Res 4: 1665-1674.

Olson ME, Fahey JW (2011) Moringa oleifera: un Arbol Multiusos par las Zonas Tropicales Secas. Revista Mexicana de Biodiversidad 82: 1071-1082.

Suganuma H, Fahey JW, Bryan KE, Healy ZR, Talalay P (2011) Stimulation of Phagocytosis by Sulforaphane. Biochem Biophys Res Commun 405: 146-151.

Zhang Y, Ahn YH, Benjamin IJ, Honda T, Hicks R, Calabrese V, Cole PA, Dinkova­Kostova AT (2011) HSF1-dependent Upregulation of Hsp70 by Sulfhydryl-reactive Inducers of the KEAP1/NRF2/ARE Pathway. Chem Biol 18: 1355-1361.

 

2010

Ahn YH, Hwang Y, Liu H, Wang, XJ, Zhang Y, Stephenson KK, Boronina TN, Cole RN, Dinkova-Kostova AT, Talalay P, Cole PA (2010) Electrophilic Tuning of the Chemoprotective Natural Product Sulforaphane. Proc Natl Acad Sci USA 107: 9590-9595.

Bensasson RV, Zoete V, Berthier G, Talalay P, and Dinkova-Kostova AT (2010) Efficacy Ranking of Triterpenoids as Inducers of a Cytoprotective Enzyme and as Inhibitors of a Cellular Inflammatory Response via their Electron Affinity and their Electrophilicity Index. Chem Biol lnteract 186: 118-126.

Bhattacharya A, Li Y, Wade KL, Paonessa JD, Fahey JW, Zhang Y (2010) Allyl Isothiocyanate-rich Mustard Seed Powder Inhibits Bladder Cancer Growth and Muscle Invasion. Carcinogenesis 31: 2105-2110.

Calabrese V, Cornelius C, Dinkova-Kostova AT, Calabrese EJ, Mattson M (2010) Cellular Stress Responses, the Hormesis Paradigm and Vitagenes: Novel Targets for Ther apeutic Intervention in Neurodegenerative Disorders. Antioxid Redox Signal 13: 1763-1811.

Calabrese V, Perluigi M, Cornelius C, Coccia R, DiDomenico F, Pennisi J, Chiara C, Dinkova-Kostova AT. (2010) Phenolics in Aging and Neurodegenerative Disorders. In: Plant Phenolics and Human Health: Biochemistry, Nutrition and Pharmacology, Fraga CG, ed. John Wiley & Sons Inc., Hoboken NJ. pp. 453-471.

Chowdhry S, Nazmy MH, Meakin PJ, Dinkova-Kostova AT, Walsh SV, Tsujita T, Dillon JF, Ashford ML, Hayes JD (2010) Loss of Nrf2 Markedly Exacerbates Non-alcoholic Steatohepatitis. Free Radical Biol Med 48: 357-371.

Dinkova-Kostova AT (2010) The Effectiveness of the Isothiocyanate Sulforaphane in Chemoprotection. Acta Horticult 867: 27-36.

Dinkova-Kostova AT, Fahey JW, Benedict AL, Jenkins SN, Ye L, Wehage SL, Talalay P (2010) Dietary Glucoraphanin-rich Broccoli Sprout Extracts Protect Against UV Radiation-induced Skin Carcinogenesis in SKH-1 Hairless Mice. Photochem Photobiol Sciences 9: 597-600.

Dinkova-Kostova AT, Talalay P (2010) NAD(P)H:Quinone Acceptor Oxidoreductase 1 (NQO1), a Multifunctional AntioxidanAntioxidant Enzyme and Exceptionally Versatile Cytoprotector. Arch Biochem Biophys 501, 116-123..

Dinkova-Kostova AT, Talalay P, Sharkey J, Zhang U, Holtzclaw WD, Wang XJ, David E, Schiavoni KH, Finlayson S, Mierke DF, Honda T (2010) An Exceptionally Potent Inducer of Cytoprotective Enzymes: Elucidation of the Structural Features That Determine Inducer Potency and Reactivity with Keap1. J Biol Chem 285: 33747-33755.

Hayes JD, McMahon M, Chowdhry S, Dinkova-Kostova AT (2010) Cancer Chemoprevention Mechanisms Mediated Through the Keap1-Nrf2 Pathway. Antioxid Redox Signal 13: 1713-1748.

Rodriguez-Cantu L, Gutierrez-Uribe J, Arreola-Vucovich J, Diaz de Ia Garza R, Fahey JW, Serna-Saldivar S (2010) Broccoli (Brassica oleracea var. italica) Sprouts and Extracts Rich in Glucosinolates and Isothiocyanates Affect Cholesterol Metabolism and Genes Involved on Lipid Homeostasis in Hamsters. J Agric Food Chem 59: 1095-1103.

Wang XJ, Hayes JD, Higgins LG, Wolf CR, Dinkova-Kostova AT (2010) Activation of the Nrf2 Signalling Pathway by Copper-mediated Redox Cycling of Para- and Ortho­Hydroquinones. Chem Biol 17: 75-85.

 

2009

Calabrese V, Cornelius C, Dinkova-Kostova AT, Calabrese EJ (2009) Vitagenes, Cellular Stress Response and Acetylcarnitine: Relevance to Hormesis. Biofactors 35: 146-160.

Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA (2009) Nitric Oxide in Cell Survival: A Janus Molecule. Antioxid Redox Signal 11: 2717-2739.

Doerr B, Wade KL, Stephenson KK, Reed SB, Fahey JW (2009) Cultivar Effect on Moringa Oleifera Glucosinolate Content and Taste: A Pilot Study. Ecology Food Nutrition 48: 199-211.

Hayes JD, Dinkova-Kostova AT, McMahon M (2009) Cross-talk Between Transcription Factors AhR and Nrf2: Lessons for Cancer Chemoprevention from Dioxin. Toxicol Sci 111: 199-201.

Healy ZR, Dinkova-Kostova AT, Wehage SL, Thompson RE, Fahey JW, Talalay P (2009) Precise Determination of the Erythe-ma Response of Human Skin to Ultraviolet Radiation and Quantification of Effects of Protectors. Photodermatol Photoimmunol Photomed 25: 45-50.

Lee SL, Stephenson KL, Fahey JW, Parsons TL, Lietman PL, Andrade AA, Lei X, Yun H, Soon GH, Shen P, Danishefsky S, Flexner C (2009) Induction of Chemoprotective Phase 2 Enzymes by Ginseng and its Components. Planta Medica 75: 1-5.

Thurber M, Fahey JW (2009) Adoption of Moringa oleifera to Combat Under-nutrition Viewed Through the Lens of the ‘Diffusion of Innovations’ Theory. Ecology Food Nutrition 48: 212-225.

Yanaka A, Fahey JW, Fukumoto A, Nakayama M, Inoue S, Zhang S, Tauchi M, Suzuki H, Hyodo I, Yamamoto M (2009) Dietary Sulforaphane-rich Broccoli Sprouts Reduce Colonization and Attenuate Gastritis in Helicobacter pylori-infected Mice and Humans. Cancer Prev Res 2: 353-360.

 

2008

Bensasson RV, Zoete V, Dinkova-Kostova AT, Talalay P (2008) Two-step Mechanism of Induction of the Gene Expression of a Prototypic Cancer-Protective Enzyme by Diphenols. Chem Res Toxicol 21: 805-812.

Calabrese V, Bates TE, Mancuso C, Cornelius C, Ventimiglia B, Cambria MT, DiRenzo L, De Lorenzo A, Dinkova-Kostova AT (2008) Curcumin and the Cellular Stress Response in Free Radical-related Disease. Mol Nutr Food Res 52: 1062-1073.

Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giufflida G, Stella AM, Schapira T, Dinkova-Kostova AT, Rizzarelli E (2008) Cellular Stress Response: A Novel Target for Chemoprevention and Nutritional Neuroprotection in Aging, Neurodegenerative Disorders and Longevity. Neurochem Res 33: 2444-2471

Dinkova-Kostova AT (2008) The Isothiocyanate Sulforaphane Induces the Phase 2 Response by Signaling of the Keap1-Nrf2-ARE Pathway: Implications for Dietary Protection Against Cancer. In: Dietary Modulation of Cell Signaling Pathways, Surh YJ, Cadenas E, Dong Z, Packer L, eds. CRC Press, Boca Raton, FL. pp. 205-227.

Dinkova-Kostova AT (2008) Phytochemicals as Protectors Against Ultraviolet Radiation: Versatility of Effects and Mechanisms. Planta Medica 74: 1548-1559.

Dinkova-Kostova AT, Fahey JW, Jenkins SN, Wehage SL, Talalay P (2008) Rapid Body Weight Gain Increases the Risk of UV Radiation-induced Skin Carcinogenesis in SKH-1 Hairless Mice. Nutr Res 28: 539-543.

Dinkova-Kostova AT, Jenkins SN, Wehage SL, Huso DL, Benedict AL, Stephenson KK, Fahey JW, Liu H, Liby KT, Honda T, Gribble GW, Sporn MB, Talalay P (2008) A Dicyanotriterpenoid Induces Cytoprotective Enzymes and Reduces Multiplicity of Skin Tumors in UV-irradiated Mice. Biochem Biophys Res Commun 367: 859-865.

Dinkova-Kostova AT, Talalay P (2008) Direct and Indirect Antioxidant Properties of Inducers of Cytoprotective Proteins. Mol Nutr Food Res 52: S128-Sl38.

Farag TH, Fahey JW, Khalfan SS, Tielsch JM (2008) Diet as a Factor in Unexpectedly Low Prevalence of Helicobacter pylori Infection. Trans Roy Soc Trop Med Hygiene 102: 1164-1165.

Liby K, Yore M, Roebuck WD, Baumgartner K, Honda T, Sundararajan C, Yoshizawa H, Gribble GW, Williams C, Risingsong R, Royce DB, Dinkova-Kostova AT, Stephenson KK, Groopman J, Kensler TW, Sporn MB (2008) A Novel Acetylene Tricyclic bis­(Cyano Enone) Potently Induces Phase 2 Cytoprotective Pathways and Blocks Liver Carcinogenesis Induced by Aflatoxin. Cancer Res 68: 6727-6733.

Liu H, Dinkova-Kostova AT, Talalay P (2008) Coordinate Regulation of Enzyme Markers for Inflammation and for Protection Against Oxidants and Electrophiles. Proc Natl Acad Sci USA 105: 15926-15931.

Munday R, Mhawech-Fauceglia P, Munday CM, Paonessa JD, Tang L, Munday JS, Lister C, Wilson P, Fahey JW, Davis W, Zhang Y (2008) Inhibition of Urinary Bladder Carcinogenesis by Broccoli Sprouts. Cancer Res 68: 1593-1600.

Ng F, Yun H, Lei X, Danishefsky SJ, Fahey JW, Stephenson KK, Flexner C, Lee L (2008) (3R,9R,10R)-Panaxytriol: a Molecular-based Nutraceutical with Possible Application to Cancer Prevention and Treatment. Tetrahedron Lett 49: 7178-7179

 

2007

Cornblatt BS, Ye L, Dinkova-Kostova AT, Erb M, Fahey JW, Singh NK, Chen M-SA, Stierer T, Garrett-Mayer E, Argani P, Davidson NE, Talalay P, Kensler TW, Visvanathan K (2007) Preclinical and Clinical Evaluation of Sulforaphane for Chemoprevention in the Breast. Carcinogenesis 28: 1485-1490.

Dinkova-Kostova AT (2007) Chemoprotection Against Cancer: An Idea Whose Time has Come. Altern Ther Health Med 13: S122-S127.

Dinkova-Kostova AT, Cory AH, Bozak RE, Hicks RJ, Cory JG (2007) Bis(2-hydroxybenzylidene)-acetone, a Potent Inducer of the Phase 2 Response, Causes Apoptosis in Mouse Leukemia Cells Through a p53-Independent, Caspase-mediated Pathway. Cancer Lett 245: 341-349.

Dinkova-Kostova AT, Fahey JW, Wade KL, Jenkins SN, Shapiro TA, Fuchs EJ, Kerns ML, Talalay P (2007) Induction of the Phase 2 Response in Mouse and Human Skin by Sulforaphane-containing Broccoli Sprout Extracts. Cancer Epidemiol Biomarkers Prev 16: 847-851.

Dinkova-Kostova AT, Cheah J, Samouilov A, Zweier JL, Bozak RE, Hicks RJ, Talalay P (2007) Phenolic Michael Reaction Acceptors: Combined Direct and Indirect Antioxidant Defenses against Electrophiles and Oxidants. Med Chem 3: 261-268.

Fahey JW, Kensler TW (2007) Role of Dietary Supplements/Nutraceuticals in Chemoprevention through Induction of Cytoprotective Enzymes. Chem Res Toxicol 20: 572-576.

Fahey JW, Stephenson KK (2007) Can Fresh Vegetable Sprouts be Produced for Human Consumption in Areas with Poor Water Quality? A Pilot Study. Trees for Life J 2: 1.

Kerns ML, DePianto D, Dinkova-Kostova AT, Talalay P, Coulombe PA (2007) Reprogramming of Keratin Biosynthesis by Sulforaphane Restores Skin Integrity in Epidermolysis Bullosa Simplex. Proc Natl Acad Sci USA 104: 14460-14465.

Mancuso C, Bates TE, Butterfield DA, Calafato S, Cornelius C, De Lorenzo A, Dinkova-Kostova AT, Calabrese V (2007) Natural Antioxidants in Alzheimer’s Disease. Expert Opin Investig Drugs 16: 1921-1931.

Liby K, Honda T, William CR, Risingsong R, Royce DB, Suh N, Dinkova­Kostova AT, Stephenson KK, Talalay P, Sundararajan C, Gribble GW, Sporn MB (2007) Novel Semisynthetic Analogues of Betulinic Acid with Diverse Cytoprotective, Antiproliferative, and Proapoptotic Activities. Mol Cancer Ther 6: 2113-2119.

Talalay P, Fahey JW, Healy ZR, Wehage SL, Benedict AL, Min C, Dinkova-Kostova AT (2007) Sulforaphane Mobilizes Cellular Defenses that Protect Skin Against Damage by UV Radiation. Proc Natl Acad Sci USA 104: 17500-17505.

Wade KL, Garrard IJ, Fahey JW (2007) Improved Hydrophilic Interaction Chromatography Method for the Identification and Quantification of Glucosinolates. J Chrom A 1154: 469-472.

Yanaka A, Hyodo I, Itoh K, Yamamoto M, Fahey JW, Talalay P (2007) Daily Intake of Sulforaphane-rich Broccoli Sprouts Improves H. pylori– induced Gastritis via Nrf2-dependent Mechanism in Mice and Human Subjects. J Clin Biochem Nutr 41(suppl): 34.

 

2006

Dinkova-Kostova AT (2006) Protection Against Cancer: The Lessons Learned and the Expectations from Targeting the Keap1-Nrf2-ARE Pathway. Am Assoc Cancer Research Education Book. Pp. 68-74.

Dinkova-Kostova AT, Jenkins SN, Fahey JW, Ye L, Wehage SL, Liby KT, Stephenson KK, Wade KL, Talalay, P (2006) Protec-tion Against UV-Light-Induced Skin Carcinogenesis in SKH-1 High-Risk Mice by Sulforaphane-containing Broccoli Sprout Extracts. Cancer Letters 240: 243-252.

Fahey JW, Ourisson PJ, Degnan FH (2006) Pathogen Detection, Testing, and Control in Fresh Broccoli Sprouts. Nutrition J 5: 5-13.

Munday R, Zhang Y, Fahey JW, Jobson HE, Munday CM, Li J, Stephenson KK (2006) Evaluation of Isothiocyanates as Potent Inducers of Carcinogen-detoxifying Enzymes in the Urinary Bladder: Critical Nature of In Vivo Bioassay. Nutrition Cancer 54: 223-231.

Shapiro TA, Fahey JW, Dinkova-Kostova AT, Holtzclaw WD, Stephenson KK, Wade KL, Ye L, Talalay, P (2006) Safety, Tolerance, and Metabolism of Broccoli Sprout Glucosinolates and Isothiocyanates: a Clinical Phase 1 Study. Nutrition Cancer 55: 53-62.

Tang L, Zhang Y, Jobson HE, Li J, Stephenson KK, Wade KL, Fahey JW (2006) Potent Activation of Mitochondria-mediated Apoptosis and Arrest in S and M Phases of Cancer Cells by a Broccoli Sprout Extract. Molec Cancer Therapeutics 5: 935-944.

Zhang Y, Munday R, Jobson HE, Munday CM, Lister C, Wilson P, Fahey JW, Mhawech-Fauceglia P (2006) Induction of GST and NQO1 in the Urinary Bladder by an Extract of Broccoli (Brassica oleracea italica) Sprouts. J Agric Food Chem 54: 9370-9376.

 

2005

Dinkova-Kostova AT, Liby KT, Stephenson KK, Holtzclaw WD, Gao X, Suh N, Williams C, Risingsong R, Honda T, Gribble GW, Sporn MB, Talalay P (2005) Extremely Potent Triterpenoid Inducers of the Phase 2 Response: Correlations of Protection Against Oxidant and Inflammatory Stress. Proc Natl Acad Sci USA 102: 4584-4589.

Dinkova-Kostova AT, Holtzclaw WD, Kensler TW (2005) The Role of Keap1 in Cellular Protective Responses. Chem Res Toxicol 18: 1779-1791.

Dinkova-Kostova AT, Holtzclaw WD, Wakabayashi N (2005) Keap1, the Sensor for Electrophiles and Oxidants that Regulates the Phase 2 Response, is a Zinc-metalloprotein. Biochemistry 44: 6889-6899.

Fahey JW (2005) Moringa oleifera: A Review of the Medical Evidence for its Nutritional, Therapeutic, and Prophylactic Proper-ties. Pt I. Trees for Life J 1:5.

Fahey JW, Stephenson KK, Dinkova-Kostova AT, Egner PA, Kensler TW, Talalay P (2005) Chlorophyll, Chlorophyllin and Related Tetrapyrroles are Significant Inducers of Mammalian Phase 2 Cytoprotective Genes. Carcinogenesis 26: 1247-1255.

Farnham MW, Stephenson KK, Fahey JW (2005) Glucoraphanin Level in Broccoli Seed is Largely Determined by Genotype. Hort Science 40: 50-53.

Fisher D, Garrard IJ, Van den Heuvel R, Sutherland IA, Chou FE, Fahey JW (2005) Technology Transfer and Scale-up of a Potential Cancer-preventive Plant [Secondary Product]: Dynamic Extraction of Glucoraphanin. J Liquid Chromatog Related Technol 28: 1913-1922.

Haristoy X, Fahey JW, Scholtus I, Lozniewski A (2005) Evaluation of Antimicrobial Effect of Several Isothiocyanates on Helicobacter pylori. Planta Medica 71: 326-330.

Healy ZR, Lee NH, Gao X, Goldring MB, Talalay P, Kensler TW, Konstantopoulos K (2005) Divergent Responses of Chondrocytes and Endothelial Cells to Shear Stress: Cross-talk Among COX-2, the Phase 2 Response, and Apoptosis. Proc Natl Acad Sci USA 102: 14010-14015.

Kensler TW, Chen J-G, Egner PA, Fahey JW, Jacobson LP, Stephenson KK, Ye L, Coady JL, Wang, J-Wu Y, Sun Y, Zhang Q-N, Zhang B-C, Zhu Y-R, Qian G-S, Carmella SG, Hecht SS, Benning L, Gange SJ, Groopman JD, Talalay P (2005) Effects of Glucosinolate-Rich Broccoli Sprouts on Urinary Levels of Aflatoxin-DNA Adducts and Phenanthrene Tetraols in a Randomized Clinical Trial in He Zuo Township, Qidong, People’s Republic of China. Cancer Epidemiol Biomarkers Prev 14: 2605-2613.

Talalay P (2005) A Fascination with Enzymes: The Journey Not the Arrival Matters. J Biol Chem 280: 28829-28847.

 

2004

Dinkova-Kostova AT, Fahey JW, Talalay P (2004) Chemical Structures of lnducers of Nicotinamide Quinone Oxidoreductase 1 (NQO1). In: Methods in Enzymology,” Quinones and Quinone Enzymes,” Sies H, Packer L, eds., vol. 382, pp. 423-448.

Fahey JW, Dinkova-Kostova AT, Stephenson KK, Talalay P (2004) The “Prochaska” Microliter Plate Bioassay for Inducers of NQO1. In: Methods in Enzymology, “Quinones and Quinone Enzymes,” Sies H, Packer L, eds., vol. 382, pp.243-258.

Fahey JW, Muñoz A, Matsuzaki Y, Suzuki H, Talalay P, Tauchi M, Zhang S, Hurt C, Yanaka A (2004) Dietary Amelioration of Helicobacter pylori Infection: Design Criteria for a Clinical Cancer Epidemiol Biomarkers Prev 13: 1610-1616.

Farnham MW, Wilson PE, Stephenson KK, Fahey JW (2004) Genetic and Environmental Effects on Glucosinolate Content and Chemoprotective Potency of Broccoli. Plant Breeding 123: 60-65.

Gao X, Talalay P (2004) Induction of Phase 2 Genes by Sulforaphane Protects Retinal Pigment Epithelial Cells from Photooxidative Damage. Proc Natl Acad Sci USA 101: 10446-10451.

Holtzclaw WD, Dinkova-Kostova AT, Talalay P (2004) Protection Against Electrophile and Oxidative Stress by Induction of Phase 2 Genes: The Quest for the Elusive Sensor that Responds to Inducers. Adv Enzyme Regulation 44: 335-367.

Kensler TW, Talalay P (2004) Inducers of Enzymes that Protect against Carcinogens and Oxidants: Drug and Food-Based Approaches with Dithiolethiones and Sulforaphane. In: Cancer Chemopreventive Agents I: Promising Cancer Chemopreventive Agents, Kelloff GJ, Hawk ET, and  Sigman CC, eds. Humana Press, Totowa, NJ. pp. 3-20.

Stephenson KK, Fahey JW (2004) Development of Tissue Culture Methods for the Rescue and Propagation of Endangered Moringa spp. Germplasm. Economic Botany 58: s116-S124.

Talalay P, Dinkova-Kostova AT (2004) Role of Nicotinamide Quinone Oxidoreductase I (NQOI) in Protection against Toxicity of Electrophiles and Reactive Oxygen Intermediates. In: Methods in Enzymology, “Quinones and Quinone Enzymes,” Sies H, Packer L, eds., vol. 382, pp.355-364.

Wakabayashi N, Dinkova-Kostova AT, Holtzclaw WD, Kang M-I, Kobayashi A, Yamamoto M, Kensler TW, Talalay P (2004) Protection Against Electrophile and Oxidant Stress by Induction of the Phase 2 Response: Fate of Cysteines of the Keap1 Sensor Modified by Inducers. Proc Natl Acad Sci USA 101: 2040-2045.

Zoete V, Rougee M, Dinkova-Kostova AT, Talalay P, Bensasson RV (2004) Redox Ranking of Inducers of a Cancer Protective Enzyme via the Energy of Their Highest Occupied Molecular Orbital. Free Radical Biol Med 36: 1418-1423

 

2003

Fahey JW (2003) “Brassicas” in Encyclopedia of Food Sciences and Nutrition, Caballero B, Trugo LC, Finglas PM, eds. Academic Press, London. pp. 606-613.

Fahey JW, Wade KL, Stephenson KK, Chou FE (2003) Separation and Purification of Glucosinolates from Crude Plant Homogenates by High-speed Counter-current Chromatography. J Chromatogr A 996: 85-93.

Farnham MW, Stephenson K, Fahey J (2003) Glucoraphanin Concentration of Broccoli Seed is Highly Influenced by Genotype. Hortscience 38: 677.

Mambo E, Gao X, Cohen Y, Guo Z, Talalay P, Sidransky D (2003) Electrophile and Oxidant Damage of Mitochondrial DNA Leading to Rapid Evolution of Homoplastic Mutations. Proc Natl Acad Sci USA 100: 1838-1843.

Talalay P, Dinkova-Kostova AT, Holtzclaw WD (2003) Importance of Phase 2 Gene Regulation in Protection Against Electrophile and Reactive Oxygen Toxicity and Carcinogenesis. Adv Enzyme Regulation 43: 121-134.

 

2002

Dinkova-Kostova AT (2002) Protection Against Cancer by Plant Phenylpropenoids: Induction of Mammalian Anticarcinogenic Enzymes. Minirev Med Chem 2: 595-610.

Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, Yamamoto M, Talalay P (2002) Direct Evidence that Sulfhydryl Groups of Keap1 are the Sensors  Regulating Induction of Phase 2 Enzymes  that Protect Against  Carcinogens and Oxidants. Proc Natl Acad Sci USA 99: 11908-11913.

Fahey JW (2002) Dietary Phytochemical Delivery: Glucosinolates/Isothiocyanates. Nutrition Today 37: 214-217.

Fahey JW, Haristoy X, Dolan PM, Kensler TW, Scholtus I, Stephenson KK, Talalay P, Lozniewski A (2002) Sulforaphane Inhibits Extracellular, Intracellular and Antibiotic-Resistant Strains of Helicobacter pylori and Prevents Benzo[a]pyrene­induced Stomach Tumors. Proc Natl Acad Sci USA 99: 7610-7615.

Fahey JW, Stephenson KK (2002) Pinostrobin from Honey and Thai Ginger (Boesenbergia pandurata): A Potent Flavonoid Inducer of Mammalian Phase 2 Chemoprotective and Antioxidant Enzymes. J Agric Food Chem 50: 7422-7476.

Fowke, JH, Hebert JR, Fahey JW (2002) Urinary Excretion of Dithiocarbamates and Self-reported Cruciferous Vegetable Intake: Application of the ‘Method of Triads’ to a Food-specific Biomarker. Pub Health Nutr 5: 791-799.

Pereira FM, Rosa E, Fahey JW, Stephenson KK, Carvalho R, Aires A (2002) Influence of Temperature and Ontogeny on the Levels of Glucosinolates in Broccoli (Brassica oleracea italica) Sprouts and their Effect on the Induction of Mammalian Phase 2 Enzymes. J Agric Food Chem 50: 6239-6244.

Ye L, Dinkova-Kostova AT, Wade KL, Zhang Y, Shapiro TA, Talalay P (2002) Quantitative Determination of Dithiocarbamates in Human Plasma, Serum, Erythrocytes, and Urine: Pharmacokinetics of Broccoli Sprout Isothiocyanates in Humans. Clin Chim Acta 316: 43-53. Erratum Clin Chim Acta 321: 127-129.

 

2001

Dinkova-Kostova AT, Massiah MA, Bozak RE, Hicks RJ, Talalay P (2001) Potency of Michael Reaction Acceptors as Inducers of Enzymes that Protect against Carcinogenesis Depends on their Reactivity with Sulfhydryl Groups. Proc Natl Acad Sci USA 98: 3404-3409.

Fahey JW, Zalcmann AT, Talalay P (2001) The Chemical Diversity and Distribution of Glucosinolates and Isothiocyanates from Plants. Phytochemistry 56: 5-51. and Corrigendum.

Fowke JH, Fahey JW, Stephenson KK, Hebert JR (2001) Using Isothiocyanate Excretion as a Biological Marker of Brassica Vegetable Consumption Epidemiological Studies: Evaluating the Sources of Variability. Pub Health Nutr 4: 837-846.

Gao X, Dinkova-Kostova AT, Talalay P (2001) Powerful and Prolonged Protection of Human Retinal Pigment Epithelial Cells, Keratinocytes, and Mouse Leukemia Cells against Oxidative Damage: The Indirect Antioxidant Effects of Sulforaphane. Proc Natl Acad Sci USA 98: 15221-15226.

Ramos-Gomez, M, Kwak M-K, Dolan PM, Itoh K, Yamamoto M, Talalay P, Kensler, TW (2001) Sensitivity to Carcinogenesis is Increased and Chemoprotective Efficacy of Enzyme Inducers is Lost in nrf2 Transcription Factor-Deficient Mice. Proc Natl Acad Sci USA 98: 3410-3415.

Shapiro TA, Fahey JW, Wade KL, Stephenson KK, Talalay P (2001) Chemoprotective Glusosinolates and Isothiocyanates of Broccoli Sprouts: Metabolism and Excretion in Humans. Cancer Epidemiol Biomarkers Prev 10: 501-508.

Talalay Pamela and Talalay Paul (2001) The Importance of Using Scientific Principles in the Development of Medicinal Agents from Plants. Academic Medicine 76: 238-247.

Talalay P, Fahey JW (2001) Phytochemicals from Cruciferous Plants Protect against Cancer by Modulating Carcinogen Metabolism. J Nutrition 131: 3027S-3033S.

Troyer JK, Stephenson KK, Fahey JW (2001) Analysis of Glucosinonlates from Broccoli and other Cruciferous Vegetables by Hydrophilic Interaction Liquid Chromatography. J Chromatogr A 919: 299-304.

 

2000

Dinkova-Kostova AT, Talalay P (2000) Persuasive Evidence the Quinone Reductase Type 1 (DT Diaphorase) Protects Cells against the Toxicity of Electrophiles and Reactive Forms of Oxygen. Free Radical Biol  and Med 29: 231-240.

Faig M, Bianchet MA, Talalay P, Chen S, Winski S, Ross D, Amzel LM (2000) Structures of Recombinant Human and Mouse NAD(P)H:Quinone Oxidoreductases: Species Comparison and Structural Changes  with Substrate Binding and Release. Proc Natl Acad Sci USA 97: 3177-3182.

Farnham, MW, Stephenson KK, Fahey JW (2000) The Capacity of Broccoli to Induce a Mammalian Chemoprotective Enzyme Varies Among Inbred Lines. J Amer Soc Hort Sci 125(4): 482-488.

Foster CE, Bianchet MA, Talalay P, Faig M, Amzel LM (2000) Structures of Mammalian Cytosolic Quinone Reductases. Free Radical Biol and Med 29: 241-245.

Talalay P (2000) Chemoprotection against Cancer by Induction of Phase 2 Enzymes. BioFactors 12: 5-11.

 

1999

Dinkova-Kostova AT, Talalay P (1999) Relation of Structure of Curcumin Analogs to their Potencies as Inducers of Phase 2 Detoxication Enzymes. Carcinogenesis 20: 911-914.

Fahey JW, Clevidence BA Russell RM (1999) Methods for Assessing the Biological Effects of Specific Plant Components. Nutrition Reviews 57(9): S34-S40.

Fahey JW, Stephenson KK (1999) Cancer Chemoprotective Effects of Cruciferous Vegetables. HortScience 34: 1159-1163.

Fahey JW, Talalay P (1999) Antioxidant Functions of Sulforaphane: A Potent Inducer of Phase 2 Detoxication Enzymes. Food Chem Toxicol 37: 973-979.

Foster CE, Bianchet MA, Talalay P, Zhao Q, Amzel LM (1999) Crystal Structure of Human Quinone Reductase Type 2, a Metalloflavoprotein. Biochemistry 389881-9886.

Khachik F, Bertram JS, Huang M-T, Fahey JW, Talalay P (1999) Dietary Carotenoids and their Metabolites as Potentially Useful Chemoprotective Agents against Cancer. In: Antioxidant Food Supplements in Human Health, Packer, M. Hiramatsu, T. Yoshikawa, eds. Academic Press, San Diego CA. pp. 203-229.

Shikita M, Fahey JW, Golden T, Holtzclaw WD, Talalay P (1999) An Unusual Case of ‘Uncompetitive Activation’ by Ascorbic Acid: Purification and Kinetic Properties of a Myrosinase from Raphanus Sativus Biochem J 341: 725-732.

Talalay P (1999) The War Against Cancer: New Hope. Proc Amer Philosophical Soc 143: 52-72.

 

1998

Dinkova-Kostova AT, Abeygunawardana C, Talalay P (1998) Chemoprotective Properties of Phenylpropenoids, bis(benzylidene)cycloalkanones and Related Michael Reaction Acceptors: Correlation of Potencies as Phase 2 Enzyme Inducers and Radical Scavengers. J Med Chem 41: 5287-5296.

Fahey JW (1998) Underexploited African Grain Crops: A Nutritional Resource. Nutrition Reviews 56: 282-285.

Fahey JW, Stephenson KK, Talalay, P (1998) Glucosinolates, Myrosinase and Isothiocyanates. In Functional Foods for Disease Prevention. 1 Fruits, Vegetables, and Teas. ShibamotoT, Terao T, Osawa T, eds. American Chemical Society, Washington, DC. pp: 16-22.

Shapiro TA, Fahey JW, Wade KL, Stephenson KK, Talalay P (1998) Human Metabolism and Excretion of Cancer Chemoprotective Glucosinolates and Isothiocyanates of Cruciferous Vegetables. Cancer Epidemiol Biomarkers Prev 7: 1091-1100.

Zhang Y, Talalay P (1998) Mechanism of Differential Potencies of lsothiocyanates as Inducers of Anticarcinogenic Phase 2 Enzymes. Cancer Research 58: 4632-4639.

 

1997

Fahey JW, Zhang Y, Talalay P (1997) Broccoli Sprouts: An Exceptionally Rich Source of lnducers of Enzymes that Protect Against Chemical Carcinogens. Proc Natl Acad Sci USA 94: 10367-10372

Zhao Q, Yang XL, Holtzclaw WD, Talalay P (1997) Unexpected Genetic and Structural Relationships of a Long Forgotten Flavoenzyme to NAD(P)H:Quinone Reductase (DT Diaphorase). Proc Natl Acad Sci USA 94: 1669-1674.

 

1996

Prestera T, Fahey JW, Holtzclaw WD, Abeygunawardana C, Kachinski JL, Talalay P (1996) Comprehensive Chromatographic and Spectroscopic Methods for the Separation and Identification of Intact Glucosinolates. Anal Biochem 239: 168-179.

Talalay P, Zhang Y (1996) Chemoprotection Against Cancer by Isothiocyanates and Glucosinolates. Biochem Soc Trans 24: 806-810.

Zhang Y, Wade KL, Prestera T, Talalay P (1996) Quantitative Determination of Isothiocyanates, Dithiocarbamates, Carbon Disulfide, and Related Thiocarbonyl Compounds by Cyclocondensation with 1,2-Benzenedithiol. Anal Biochem 239: 160-167.

 

1995

Fahey JW, Talalay P (1995) The Role of Crucifers in Cancer Chemoprotection. In: Phytochemicals and Health, Vol. 15, Gustine DL, Flores HE, eds. American Society of Plant Physiologists. pp. 87-93.

Kolm RH, Danielson UH, Zhang Y, Talalay P, Mannervik B (1995) Isothiocyanates as Substrates for Human Glutathione Transferases: Structure-Activity Studies. Biochem J 311: 453-459.

Prestera T, Talalay P, Alam J, Ahn YI, Lee PJ, Choi AMK (1995) Parallel Induction of Heme Oxygenase and Chemoprotective Phase 2 Enzymes by Electrophiles and Antioxidants: Regulation by Upstream Antioxidant-Responsive Elements (ARE). Molec Med 1: 827-837.

Prestera T, Talalay P (1995) Electrophile and Antioxidant Regulation of Enzymes that Detoxify Carcinogens. Proc Natl Acad Sci USA 92: 8965-8969.

Putzer RR, Zhang Y, Prestera T, Holtzclaw WD, Wade KL, Talalay P (1995) Mercurials and Dimercaptans: Synergism in the Induction of Chemoprotective Enzymes. Chem Res Toxicol 8: 103-110.

Talalay P, Fahey JW, Holtzclaw WD, Prestera T, Zhang Y (1995) Chemoprotection Against Cancer by Phase 2 Enzyme Induction. Toxicol Lett 82/83: 173-179.

Zhang Y, Kolm RH, Mannervik B, Talalay P (1995) Reversible Conjugation of Isothiocyanates with Glutathione Catalyzed by Human Glutathione Transferases. Biochem Biophys Res Commun 206: 748-755

 

1994

Chen S, Clarke PE, Martino PA, Deng PSK, Yeh C-H, Lee TD, Prochaska HJ, Talalay P (1994) Mouse Liver NAD(P)H:Quinone Acceptor Oxidoreductase: Protein Sequence Analysis by Tandem Mass Spectrometry, cDNA Cloning, Expression in Escherichia coli, and Enzyme Activity Analysis. Protein Science 3: 1296-1304.

Egner PA, Kensler TW, Prestera T, Talalay P, Libby AH, Joyner HH, Curphey TJ (1994) Regulation of Phase 2 Enzyme Induction by Oltipraz and Other Dithiolethiones. Carcinogenesis 15: 177-181.

Posner GH, Cho C-G, Green JV, Zhang Y, Talalay P (1994) Design and Synthesis of Bifunctional Isothiocyanate Analogs of Sulforaphane: Correlation between Structure and Potency as Inducers of Anticarcinogenic Detoxication Enzymes. J Med Chem 3: 170-176.

Zhang Y, Kensler TW, Cho C-G, Posner GH, Talalay P (1994) Anticarcinogenic Activities of Sulforaphane and Structurally Related Synthetic Norbornyl Isothiocyanates. Proc Natl Acad Sci USA 91: 3147-3150. 

Zhang Y, Talalay P (1994) . Cancer Res (Suppl) 54: 1976s-1Anticarcinogenic Activities of Organic Isothiocyanates: Chemistry and Mechanisms981s.

 

1993

Kensler TW, Davidson NE, Groopman JD, Roebuck BD, Prochaska HJ, Talalay P (1993) Chemoprotection by Inducers of Electrophile Detoxification Enzymes. In: Antimutagenesis and Anticarcinogenesis Mechanisms III, Bronzetti G et al, eds. Plenum Press, New York. pp. 127-136. 

Prestera T, Holtzclaw WD, Zhang Y, Talalay P (1993) Chemical and Molecular Regulation of Enzymes that Detoxify Carcinogens. Proc Natl Acad Sci USA 90: 2965-2969.

Prestera T, Zhang Y, Spencer SR, Wilczak CA, Talalay P (1993) The Electrophile Counterattack Response: Protection Against Neoplasia and Toxicity. Adv Enzyme Regulation 33: 281-296.

Prochaska HJ, Santamaria AB, Talalay P (1993) Rapid Detection of lnducers of Enzymes that Protect Against Carcinogens. In: Food and Cancer Prevention: Chemical and Biological Aspects, Waldron KW, Johnson LT, Fenwick GR, eds. The Royal Society of Chemistry, Cambridge, England. pp. 411-415.

Zhang Y, Cho C-G, Posner GH, Talalay P (1993) Quantitation of lsothiocyanates by Cyclocondensation with 1,2-Benzenedithiol. In: Food and Cancer Prevention: Chemical and Biological Aspects, Waldron KW, Johnson LT, Fenwick GR, eds. The Royal Society of Chemistry, Cambridge, England. pp. 421-425.

Zhang Y, Talalay P, Cho C-G, Posner GH (1993) Isolation and Identification of the Principal Inducer of Anticarcinogenic Protective Enzymes from Broccoli. In: Food and Cancer Prevention: Chemical and Biological Aspects, Waldron KW, Johnson LT, and Fenwick GR, eds. The Royal Society of Chemistry, Cambridge, England. pp. 416-420.

 

1992

Prestera T, Prochaska HJ, Talalay P (1992) Inhibition of NAD(P)H:(Quinone Acceptor) Oxidoreductase by Cibacron Blue and Related Anthraquinone Dyes: A Structure-Activity Study. Biochemistry 31: 824-833.

Prochaska HJ, Santamaria AB, Talalay P (1992) Rapid Detection of lnducers of Enzymes that Protect Against Carcinogens. Proc Natl Acad Sci USA 89: 2394-2398.

Prochaska HJ, Talalay P (1992) Phenolic Antioxidants as Inducers of Anticarcinogenic Enzymes. In: Phenolic Compounds in Food and their Effects on Health II: Antioxidants and Cancer Prevention, Huang MT, Ho CT, Lee CY, eds. American Chemical Society, Washington, DC. pp. 150-159.

Talalay P (1992) Chemical Protection against Cancer by Induction of Electrophile Detoxication (Phase II) Enzymes. In: Cellular and Molecular Targets of Chemoprevention, Steele VE, Stoner GD, Boone CW, Kelloff GJ, eds. CRC Press, Boca Raton, FL. pp. 193-205.

Talalay P (1992) The Role of Enzyme Induction in Protection Against Carcinogenesis. In: Cancer Chemoprevention, Wattenberg L, Lipkin M, Boone CW, Kelloff GJ, eds. CRC Press, Boca Raton, FL. pp. 469-478.

Zhang Y, Talalay P, Cho C-G, Posner GH (1992) A Major Inducer of Anti­carcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc Natl Acad Sci USA 89: 2399-2403.

Zhang Y, Cho C-G, Posner GH, Talalay P (1992) Spectroscopic Quantitation of Organic Isothiocyanates by Cyclocondensation with Vicinal Dithiols. Anal Biochem 205: 100-107.