The byproduct of a reaction between two compounds (glucosinolates and myrosinase) found in the leaves and stems of cruciferous vegetables. Isothiocyanates inhibit phase 1 biotransformation enzymes (enzymes that transform procarcinogens into carcinogens) and activate phase 2 detoxification enzymes (enzymes that protect cells and DNA from free radicals and carcinogens). Examples of phase II enzymes include UDP-glucuronosyltransferases, sulfotransferases, N-acetyltransferases, glutathione S-transferases, and methyltransferases.

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